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M9480077.TXT
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1994-08-09
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Document 0077
DOCN M9480077
TI Intraepithelial lymphocyte subpopulations and dendritic accessory cells
in normal and hypertrophic adenoids.
DT 9410
AU Bani D; Gallo O; Fini-Storchi O; Department of Human Anatomy and
Histology, University of; Florence, Italy.
SO Laryngoscope. 1994 Jul;104(7):869-73. Unique Identifier : AIDSLINE
MED/94293745
AB The adenoids have been studied by immunocytochemistry and electron
microscopy in children with and without adenoidal enlargement. Compared
with normal adenoids, the enlarged ones showed a marked increase in the
number of intraepithelial gamma-delta TCR+ lymphocytes and a slight
increase in the number of intraepithelial CD8+ lymphocytes. This was
accompanied by large amounts of dendritic human lymphocyte antigen (D
related) (HLA-DR+) S-100+ accessory cells in the lymphoid tissue
underlying the epithelium. By electron microscopy, dead epithelial cells
apposed to intraepithelial lymphocytes, and clefts of the epithelial
lamina, could be seen frequently in the enlarged adenoids, whereas, in
the normal ones, they could not. Based on these findings, the hypothesis
is drawn that imbalance of the system of the intraepithelial cytotoxic
lymphocytes may lead to increased killing of epithelial cells and
uncontrolled penetration of exogenous agents, and hence be involved in
the pathogenesis of adenoidal hypertrophy.
DE Adenoids/CYTOLOGY/METABOLISM/*PATHOLOGY Antigens, CD/BIOSYNTHESIS
Antigens, CD3/BIOSYNTHESIS Antigens, CD4/BIOSYNTHESIS Antigens,
CD8/BIOSYNTHESIS Antigens, Differentiation, B-Lymphocyte/BIOSYNTHESIS
B-Lymphocyte Subsets/METABOLISM/*PATHOLOGY Child Child, Preschool
Comparative Study CD4-CD8 Ratio Dendritic
Cells/CYTOLOGY/METABOLISM/PATHOLOGY
Epithelium/CYTOLOGY/METABOLISM/PATHOLOGY Human
Hypertrophy/METABOLISM/PATHOLOGY HLA-DR Antigens/BIOSYNTHESIS
Immunohistochemistry Microscopy, Electron Nerve Tissue Protein S
100/BIOSYNTHESIS Receptors, Antigen, T-Cell, gamma-delta/BIOSYNTHESIS
T-Lymphocyte Subsets/METABOLISM/*PATHOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).